Ten years ago few people could imagine that one day men will be able to stay sexually active within 36 hours in a row. Before Cialis appeared on retail sale, there were no drugs, able to make men with erectile dysfunction sexually active any time of day and night.
Thus only Cialis can do this job and provide men with erection within 36 hours. While the pharmacological activity of some alternative erectile dysfunction drugs is usually 4 hours maximum.
Such unbelievable duration of pharmacological effect, makes Cialis increasingly popular on the global pharmaceutical market. Though we should admit that Cialis stays both the most effective and one of the most expensive ED drugs ever. This makes Cialis quite unpurchasable for many men these days.
If you were prescribed with Cialis, but these ED drug is very pricey at the regional pharmacy chains, our online pharmacy offers you to buy Cialis online at discount. In order to buy Cialis online, you will not have to fill in medical questionnaire. But if you decided to buy Cialis online without prescription, you can always use professional consultation of our pharmacist.
Indications for use of Cialis
Cialis is indicated for the treatment of erectile dysfunction (ED) in:
- Young men of 18 years old (included) and older;
- Men of mature age;
- Elderly men over 65 years old.
Cialis mechanism of action
Each oral pill of Cialis contains active pharmaceutical substance, called Tadalafil. According to pharmacological classification, Tadalafil is a phosphodiesterase type 5 inhibitor (PDE5 inhibitor). As any other PDE5 inhibitor, Tadalafil is able to intensify the blood flow to the erectile tissue of the penis.
As a result of enhanced blood flow in the penis, erectile function is completely restored. Herewith Cialis (Tadalafil) helps men to stay sexually active within 36 hours, even if the ability to achieve erection has been completely lost before the onset of ED drug therapy.
Contraindications for Cialis use
Cialis must not be taken by men:
- with severe cardiovascular pathologies;
- who are taking organic nitrates (such as nitroglycerin);
- with diagnosed allergy to the active and (or) inactive pharmaceutical ingredients of Cialis.
Given that women have not been involved in clinical studies of the active substance Tadalafil, Cialis tablets must not be prescribed for the treatment of sexual disorder in women.
Cialis Side effects
According to published clinical studies, approximately 15% of men, taking maximum daily dose of Cialis 20mg, have experienced headaches as a side effect. About 10% of men, who were taking Cialis 20mg, have had gastrointestinal side effects. And about 5% of men, taking the maximum Cialis dose, have suffered from back pain. In single case, Cialis pills caused redness of the face, stuffy nose, muscle pain and pain of the limbs.
Recommended dose of Cialis
Single dose of Cialis should be taken 30-60 minutes before sexual intercourse, but no more than once a day. Men are allowed to take Cialis pills even after taking small amount of alcohol. The meal time have no impact on the onset and duration rate of the pharmaceutical effect of Cialis.
- For daily sexual activity, men are enough to take just one Cialis 5mg pill, once daily.
- The average dose is Cialis 10mg.
- Men with severe erectile dysfunction can be prescribed with the recommended daily dose of Cialis 20mg.
Different groups of drugs can affect the pharmaceutical features of Cialis. Therefore man should read carefully the information on Cialis drug interaction, before adding Cialis to the combined drug therapy.
Interactions between Cialis pills and other drugs
Drugs that are potent CYP3A4 inhibitors, can enhance pharmacological effect of Cialis pills. Therefore after the use of such drugs, reduction of Cialis daily dose is required as a rule. Doctor can reduce the daily dose of Cialis drug or recommend to stop taking Cialis pills if during the period of medical therapy of erectile dysfunction, men were prescribed:
- Antifungal drug Ketoconazole (trade names: Nizoral; Extina; Xolegel; Ketozole);
- macrolide antibiotic Erythromycin (trade names: Erythrocin; E-Mycin; Robimycin; EES; Sansac; Eryacne; Staticin; Eryc);
- anti-HIV drug Ritonavir (trade names: Kaletra; Norvir);
- anti-HIV drug Saquinavir (trade names: Fortovase; Invirase).
All these drugs are inhibitors of CYP3A4, which may interact with Cialis drug, increasing its pharmacological properties. After the use of Cialis pills together with drugs listed above, side effects may occur. To ease these side effects, patients might need a symptomatic treatment (gastric lavage, absorbent carbon).
Some drugs do not increase, but on contrary reduce pharmacological effect of Cialis drug. For instance, bactericidal antibiotic Rifampicin can reduce the concentration of Tadalafil (active ingredient of Cialis pills) in the blood plasma. It means that men, who take Rifampicin, may not achieve therapeutic effect they were expecting from Cialis pills. Rifampicin antibiotic is available at pharmacies under the trade names Rifadin and Rimycin.
There are also such drugs that delay the onset of Cialis therapeutic effect. For example, antacids Gaviscon and Foamicon reduce the absorption rate of Tadalafil in the gastrointestinal tract. That means men, taking antacids, are recommended to use Cialis pills not an hour, but two hours prior sexual intercourse.
Noteworthy that not only other drugs can affect the pharmacological effect of Cialis, but Cialis itself does influence on the properties of other drugs. Herewith the impact of Cialis on some other drugs can cause quite severe side effects. Moreover, some group of drugs must never be taken along with Cialis.
First of all, Cialis pills cannot be taken by men, who use nitrates, such as for example Nitroglycerin (trade names: Nitromist; Minitran; Tridil; Nitro IV; Transderm-Nitro; Nitro-Bid; Rectiv; Nitro-Dur; Nitrostat; Nitrol; Nitronal; Nitrolingual).
Cialis enhances hypotensive activity of nitrates, so their combined use may provoke a sudden drop of blood pressure. That's why, Cialis pills are contraindicated for men, who take nitrates.
If you are going to buy Cialis online without prescription and you are going to take this drug along with other drugs, please consult our online pharmacists before placing your order.
